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Symptoms & complaints

Stress, burnout and your blood

Long-term stress can affect the whole body, but burnout cannot be diagnosed with a blood test. Blood testing can, however, reveal or rule out physical causes that produce symptoms resembling overload, such as a thyroid problem or a vitamin deficiency. That way a treatable problem is not mistaken for stress. Below you can read what cortisol and the other relevant values do and do not tell you with stress complaints, and what a normal result then means.

Medically reviewed by the Bloodworks medical team

6 min readBy the Bloodworks editorial team

In short

  • A blood test does not diagnose burnout. It rules out physical causes that resemble burnout.
  • Thyroid, anaemia and a deficiency of vitamin B12 or D cause symptoms that closely resemble it.
  • Cortisol alone rarely explains anything: a single measurement says little about prolonged stress.
  • Normal values do not mean your symptoms are not there. They mean the cause lies elsewhere.

What you can measure

Not every cause is visible in blood. These are the values that most often explain something.

Recommended test

Recommended for prolonged stress symptoms

Fatigue & Sleep

8 markers

Rules out the physical contributing factors that more often do yield something in prolonged stress.

  • Personal assessment by a registered doctor
  • Clear laboratory report, in plain language
  • No referral needed
  • 1000+ blood draw locations

€219

Plus 29,- blood draw fee per order, free from 225,-.

View this test

Complete pictureBloodworks Premium

36 markers in one appointment

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Prefer something else?Cortisol€40

What blood testing can and cannot do for stress symptoms

Burnout or being overstressed is not a laboratory diagnosis. A GP or occupational health physician establishes it based on your symptoms, your story and your functioning. There is no blood value that proves or rules out burnout, not even the stress hormone cortisol.

What blood testing can do is reveal or rule out physical causes that produce symptoms resembling stress. Think of a thyroid that runs too slow or too fast, or a deficiency of vitamin D or iron. Those causes are treatable, and that is exactly why it would be a shame to miss them when every symptom is attributed to stress.

Cortisol: the stress hormone in context

Cortisol is often called the stress hormone. It helps the body respond to exertion and tension and can be associated with prolonged strain. Yet it is a difficult value to interpret. Cortisol fluctuates strongly over the day: in the morning the value usually differs from the evening. Sleep, medication and the moment of collection also play a part.

A single measurement therefore neither proves nor rules out burnout. An unremarkable result does not exclude long-term stress, and an abnormal result does not make burnout certain. Our doctor weighs the time of collection and your situation in the written explanation, and notes when a repeat measurement or further assessment can be useful.

What can look like stress

Several physical causes produce symptoms that closely resemble overload: tiredness, irritability, poor sleep and trouble concentrating. A slow thyroid can show as fatigue and low mood; a fast thyroid as restlessness, palpitations and agitation. TSH is the first measurement for this.

A deficiency of vitamin D or of iron can also fit persistent tiredness and low energy. These causes are treatable. Ruling them out prevents a physical problem from being mistaken for stress for months, and the other way around.

If your results are normal

With stress symptoms, a normal result is valuable information. The most common physical causes have then become unlikely. That does not mean your symptoms are not real; it means the explanation probably lies elsewhere, in workload, recovery and circumstances.

The next step is then not another test, but recovery: taking rest, restoring the balance between exertion and relaxation, and seeking support. Your GP or occupational health physician is the right route for that. A recent, doctor-reviewed result helps that conversation: the physical side has already been examined.

Frequently asked questions

Can you see burnout in your blood?

No. Burnout is diagnosed based on your symptoms and functioning, usually by a GP or occupational health physician. Blood testing can rule out physical causes that resemble the same symptoms.

What does a cortisol measurement tell you?

Cortisol is the stress hormone and fluctuates strongly over the day. A single measurement neither proves nor rules out burnout; a doctor weighs the time of collection and your situation in the interpretation.

Which physical causes resemble stress symptoms?

A slow or fast thyroid, a vitamin D deficiency and an iron deficiency can cause symptoms that resemble overload: tiredness, irritability and poor sleep. Blood testing can reveal or rule out these causes.

Do I need to fast?

For these markers fasting is usually not needed. For cortisol the time of collection does matter; that measurement is preferably done in the morning.

What if my results are normal?

Then the most common physical causes have become unlikely. Your symptoms remain real; the next step is recovery and support.

Sources

Recommended test

Recommended for prolonged stress symptoms

Fatigue & Sleep

8 markers

Rules out the physical contributing factors that more often do yield something in prolonged stress.

  • Personal assessment by a registered doctor
  • Clear laboratory report, in plain language
  • No referral needed
  • 1000+ blood draw locations

€219

Plus 29,- blood draw fee per order, free from 225,-.

View this test

Complete pictureBloodworks Premium

36 markers in one appointment

View Premium€399
Prefer something else?Cortisol€40

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